pentobarbital will reduce the extent or result of prednisone by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.pentobarbital boosts toxicity of ifosfamide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe. CYP3A4 inducers may perhaps improve the metabolism of ifosfamide to its Lively a